目錄
Chapter 1 Introduction
Liu Xiaoli, Ouyang Xiaoxi, and Li Lanjuan
1.1 Concept and Classification of Artificial Liver System
1.2 Developments of Artificial Liver Systems
1.3 History of Artificial Liver Research Carried out by Li Lanjuan's Research Team at Zhejiang University
1.4 Summary
Chapter 2 Liver Structure
Zhang Sainan, Chen Wenqian, and Zhu Chunxia
2.1 Anatomy of the Liver
2.2 Hepatic Histology
2.3 Ultrastructure of Liver Cells
Chapter 3 Liver Function
Hao Shaorui
3.1 Energy Metabolism and Its Regulation in the Liver
3.2 Substance Metabolism and Its Function in the Liver
3.3 Synthesis and Secretion of the Bile
3.4 Immunological Function of the Liver
Chapter 4 Liver Regeneration and Tissue Engineering
Zhou Qian, Fan Linxiao, and Li Jun
4.1 Process and Regulation of Liver Regeneration
4.2 Liver Tissue Engineering and Liver Regeneration
4.3 Clinical Application of Engineered Liver
Chapter 5 Etiology of Liver Injury
Chen Chunlei, Wu Wenrui, and Li Yongtao
5.1 Infection
5.2 Drugs and Toxicants
5.3 Alcohol
5.4 Heredity and Metabolism
5.5 Autoimmune Liver Disease
5.6 Tumor
5.7 Others
Chapter 6 Pathogenesis of Liver Injury and Hepatic Failure
Yu Liang
6.1 Summary
6.2 Pathogenesis of Viral Induced Liver Injury/Liver Failure
6.3 Drug Induced Liver Injury/Liver Failure
6.4 Other Factors Induced Liver Injury/Liver Failure
6.5 Pathogenesis of Chronic Liver Failure
6.6 Pathogenesis of Complications of Liver Failure
Chapter 7 Liver Pathology
Cheng Jinlin and Wang Zhaoming
7.1 Histochemical and Immunohistochemical Stains
7.2 Pathological Changes in the Liver
7.3 Pathological Changes in Liver Failure
Chapter 8 Laboratory Evaluation of Liver Failure
Chen Yu
8.1 Detection of Pathogenic Infection
8.2 Assessment of Metabolic Balance
8.3 Evaluation of Hepatorenal Syndrome
8.4 Evaluation of Hepatic Encephalopathy
8.5 Detection of Coagulation
8.6 Detection of Anaphylaxis
Chapter 9 Imaging Examination of Liver Failure
Jiang Tian'an, Yu Linya, Zhao Yilei, and Wang Baohua
9.1 Ultrasonic Diagnosis of Severe Liver Failure
9.2 CT and MR Examinations of the Liver
9.3 Normal CT and MR Appearances of the Liver
9.4 CT, MRI Findings of Liver Failure
Chapter 10 Diagnosis of Liver Failure
Cao Qing and Yu Chengbo
10.1 Definition and Classification of Liver Failure
10.2 Stages of Liver Failure
10.3 Diagnosis of Liver Failure
10.4 Dynamics of Liver Function and Prognosis of Liver Failure
10.5 Significance of the Immune Molecules in the Diagnosis of Liver Failure
10.6 Prognoses of Liver Failure
Chapter 11 Internal Medical Treatment of Liver Failure
Jiang Zhengyi and Chen Jiajia
11.1 Medical Monitoring
11.2 Specific Nutrition and Metabolic Support Therapy
11.3 Targeting Etiologies and Pathogenesis
11.4 Promote the Growth of Hepatocytes and the Removal of Jaundice
11.5 Prevention and Treatment of Complications
Chapter 12 Mechanism for the Functioning of the Artificial Liver
Bao Qionglng, Guo Jing, Chen Yanfei, Yang Fengling, and Li Lanjuan
12.1 Artificial Liver and Liver Functions
12.2 Artificial Liver and Toxic Metabolites
12.3 Artificial Liver and Microecology
12.4 Artificial Liver and the Internal Environment
12.5 Cytokines in Artificial Liver Support Systems
Chapter 13 Non-Bioartificial Liver
Xie Zhongyang, Zhao Yalei, Zhu Danhua, Xu Xiaowei, Yang Qian, and Li Lanjuan
13.1 Membrane Filter and Absorber
13.2 Li-NBAL
13.3 Other Non-Biological Artificial Livers
13.4 Indications and Contraindications for Artificial Liver Systems in Liver Failure
Chapter 14 Operation and Management of Artificial Liver Support Systems
Zhang Xiaoqian and Zhang Huafeng
14.1 Management of Non-Biological Artificial Liver System
14.2 Operation and Nursing of Non-Bioartificial Liver Support Therapy
14.3 Anticoagulation Method
Chapter 15 Artificial Liver Support System: Complications and Prevention
Xu Xiaowei, Violetta Laurencia, and Xie Zhongyang
15.1 Bleeding and Clot Formation
15.2 Hypotension
15.3 Secondary Infections
15.4 Allergic Reactions
15.5 Hemolysis
15.6 Other Complications
Chapter 16 Efficacy and Its Evaluation of Non-Bioartificial Liver
Li Zuhong and Xia Qi
16.1 Criteria and Indicators of Efficacy of Non-Bioartificial Liver
16.2 Efficacy of Non-Bioartificial Liver
16.3 MELD for Predication of Curative Effect in Liver Failure Treatment Via Non-Bioartificial Liver
Chapter 17 Bioartificial Liver
Zhang Yanhong, Lu Juan, Fei Yang, Wang Jie, Pan Xiaoping, and Li Lanjuan
17.1 Principle of the Bioartificial Liver
17.2 Bioartificial Liver System
17.3 Animal Models for Evaluating Bioartificial Liver
Chapter 18 Hybrid Artificial Liver
Zhang Yimin, Huang Kaizhou, Zhu Danhua, and Li Lanjuan
18.1 Construction of Hybrid Artificial Liver
18.2 Animal Experiment Evaluation Using the Hybrid Artificial Liver (HAL)
18.3 Hybrid Artificial Liver Clinical Trials
Chapter 19 Cell Transplantation Therapy for Liver Failure
Hu Chenxia, Yu Jiong, Cao Hongcui, and Li Jun
19.1 Basic Study of Hepatocyte Transplantation
19.2 Clinical Application of Cell Transplantation
19.3 Problems and Prospects of Hepatocyte Transplantation
Chapter 20 Artificial Liver and Liver Transplantation
Chen Diyu, Shen Tian, and Wu Jian
20.1 A Brief Introduction to Liver Transplantation
20.2 Indications for Liver Transplantation, Contraindications and Timing of Surgery
20.3 Application of Liver Transplantation to Treat Liver Failure
Chapter 21 Clinical Cases
Chen Jiajia, Hao Shaorui, Liu Xiaoli, Yu Liang, Zhu Mengfei, Dai Xiahong, and Li Lanjuan
21.1 Case 1: Li-ALS Treatment for Viral Liver Failure
21.2 Case 2: Li-ALS Treatment for Drug-Induced Liver Failure
21.3 Case 3: Li-ALS Treatment for Acute Fatty Liver of Pregnancy
21.4 Case 4: Li-ALS Therapy for Human Infection with H7N9 Influenza A Virus
21.5 Case 5: Artificial Liver Treatment of Severe COVID-19 Cases by Nurse Manager Li
21.6 Case 6 Li-ALS Therapy for Elderly Patients with Severe COVID
Chapter 22 Prospect
Du Weibo, Chen Ermei, and Li Lanjuan
22.1 Present Situation and Controversies on the Medical Treatment of Liver Failure
22.2 Developments and Prospects of Artificial Liver Therapy
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