內容大鋼
毒理學是一門關鍵的公共衛生學科，它涵蓋了有毒物質的識別、評估和管理，以及這些物質對人類健康的潛在影響。然而，目前適合國內高校教學的英語版毒理學教材的供應嚴重不足。因此，編寫一本適合國內高校全英文教學的毒理學教材對於提高大學生的毒理學教育質量至關重要。這將有助於培養具備毒理學知識和技能的健康國際化專業人員，以更好地應對現實世界中的化學物質和環境健康問題。
《毒理學教程》（Text book of Toxicology）旨在提供一本全面的、易於理解的教材，滿足大學生對毒理學教育的迫切需求，以培養更多的公共衛生專業人員和毒理學研究者。
本教材主要內容包括：1.毒物的種類和性質，對不同毒物的分類、毒性機制和影響進行深入討論。2.毒理學原理，解釋毒性的基本原理，包括劑量-效應關係、毒性動力學和毒性代謝等。3.風險評估和管理：介紹毒物風險評估方法，以及如何管理潛在的健康風險。
目錄
Contents
CHAPTER 1 Introduction to Toxicology
Definition of Toxicology
Scope of Toxicology
Multidisciplinary Nature of Toxicology
Historical Aspects of Toxicology
Methods and Types of Toxicology Studies
Challenges and Future Prospects
CHAPTER 2 Essential Concepts of Toxicology
Toxic Agents, Toxicity and Adverse Effects
Dose, Response and Dose-Response Curve
Biomarker
Common Indices of Toxicity
Evaluating the Dose-Response Relationship
Safety Limit Value
CHAPTER 3 Biological Transportation of Toxicants
Introduction
Biomembranes and Biological Transportation
Absorption of Toxicants
Distribution of Toxicants
Excretion of Toxicants
CHAPTER 4 Biotransformation of Toxicants
Introduction
Factors Influencing Biotransformation
Biotransformation Enzymes
Phase Ⅰ Reactions
Phase Ⅱ Reactions
Toxicokinetics
CHAPTER 5 Mechanisms of Toxicity
Introduction
Formation of Ultimate Toxicant
Reaction of the Ultimate Toxicant with the Target Molecule
Cellular Dysfunction
Repair or Dysrepair
CHAPTER 6 Factors Influencing Toxic Effects
Introduction
Factors Related to the Toxic Agent
Factors Influencing the Subject
Factors Influencing Exposure
External Environment Factors
Interactive Toxicity of Chemical Mixtures
CHAPTER 7 General Toxicity
Introduction
Acute Toxic Studies
Subacute, Subchronic, and Chronic Toxicity Studies
Local Toxicity Studies
CHAPTER 8 Chemical Mutagenesis
Introduction
Types of Mutation
Health Impact of Mutations
Mechanism of Mutagenesis
DNA Repair and Tolerance Pathway
Mutagenicity Testing
CHAPTER 9 Chemical Carcinogenesis
Introduction
Mechanism of Chemical Carcinogenesis
Multi-stage Processes of Carcinogenesis
Carcinogen Classification
Identification of Carcinogen
CHAPTER 10 Developmental Toxicity and Teratogenesis
Introduction
Principles of Developmental Toxicology
Maternal Toxicity and Developmental Toxicity
Cases of Human Developmental Toxicants
Mechanisms of Developmental Toxicity
Safety Assessment and Testing
CHAPTER 11 Regulatory Toxicology
Introduction
The Science/Policy Interface in Regulatory Toxicology
Regulatory Agencies and Statutes
An Overview of Regulatory Approaches
Regulatory Influences on Toxicology
Risk Assessment Basics
Four Steps Process for Risk Assessment
Risk Management
Risk Communication
International Harmonization and Collaboration on Regulatory Toxicology
Specific Regulatory Programs Utilizing Toxicological Data
CHAPTER 12 Immunotoxicology
Introduction
The Structure and Functions of Immune System
Types of Immunotoxic Responses
Mechanisms of Immunotoxicity
Key Research Areas in Immunotoxicology
Immunotoxicology Testing Methods
Risk Assessment in Immunotoxicology
Common Immunotoxicants
Drugs and Immune System Interaction
Advances in Immunotoxicology Research
Global Challenges, Opportunities and Prospect
CHAPTER 13 Toxicology of the Liver
Introduction
Structure and Functions of the Liver
Types and Mechanisms of Toxic Liver Injury
Toxicants and Their Effects
Testing Procedure and Evaluation
CHAPTER 14 Toxicology of the Kidney
Introduction
Structure and Functions of the Kidney
Mechanisms of Renal Cell Injury
Sites and Types of Toxic Responses of the Kidney
Pathophysiologic Responses of the Kidney
Assessment of Renal Toxicity
Specific Nephrotoxicants
CHAPTER 15 Neurotoxicology
Introduction
Structure and Functions of the Nervous System
Toxicant Effects on the Nervous System
Neurotoxicity Testing: Methods and Approaches
CHAPTER 16 Reproductive Toxicology
Introduction
Male Reproductive Toxicity
Female Reproductive Toxicity
Reproductive Toxicity Testing and Evaluation
CHAPTER 17 Nanotoxicology
Introduction
Physicochemical Factors Relevant for Toxicity
"Nano-Bio" Interface
"ADME" of NMs
Toxicity Mechanisms and Research Methods
Limitations and Future Directions
CHAPTER 18 Toxic Effects of Radiation and Radioactive Materials
Introduction
Source and Characteristics of Ionizing Radiation
Physicochemical Basis of Ionizing Radiation-Induced Damage
Biological Effects of Ionizing Radiation
The Biological Effects o
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