1. Introduction 1.1 Background and motivation 1.2 Content and objectives 2. The HLRP and relevant researches 2.1 The hub location problem 2.2 The location - routing problems 2.3 The hub location - routing problem 2.4 Environmental considerations 2.5 Conclusions and research proposals 3. Mathematical model of the HLRP for minimizing cost 3.1 Problem definition 3.2 A mathematical model for the single - objective HLRP 3.3 Conclusion 4. A memetic algorithm for the single - objective HLRP 4.1 An overview of the memetic algorithm 4.2 Algorithmic design of the MA for the HLRP 4.3 Conclusion 5. Computational experiments for the single - objective HLRP 5.1 Data and parameters 5.2 CPLEX assessments 5.3 MA assessments 5.4 Analysis of computational results 5.5 Sensitivity analysis 5.6 Conclusion 6. A mathematical model and a MA for the bi - objective HLRP 6.1 Problem definition 6.2 Emission formulations 6.3 A bi - objective model for Green HLRP 6.4 A memetic algorithm for the bi - objective HLRP 6.5 Conclusion 7. Computational experiments for the bi - objective HLRP 7.1 Data set 7.2 Epsilon constraint method 7.3 Parameter settings for the bi - objective MA 7.4 Results analysis 7.5 Performance assessment of the bi - objective MA 7.6 Conclusion 8. Two - phase model and memetic algorithm 8.1 Two - phase model for minimizing cost 8.2 Two - phase MA for minimizing cost 8.3 Conclusion 9. Computational experiments of the two - phase method 9.1 Data set 9.2 CPLEX results of the two - phase model 9.3 MA results of the two - phase method 9.4 Conclusion 10. General conclusions and prospects Afterword Bibliography Keywords