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細胞編程與重編程的表觀遺傳機制(英文版)(精)/中國基礎研究報告

  • 作者:編者:裴鋼|責編:金蕾|總主編:楊衛
  • 出版社:浙江大學
  • ISBN:9787308227568
  • 出版日期:2022/06/01
  • 裝幀:精裝
  • 頁數:65
人民幣:RMB 58 元      售價:
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內容大鋼
    本書為「中國基礎研究報告」叢書《細胞編程與重編程的表觀遺傳機制》英文版,基於重大研究計劃「細胞編程與重編程的表觀遺傳機制」的研究成果寫作完成。該重大研究計劃歷時8年,資助總經費1.9億元,申請項目涉及生命、化學和信息等學部,取得了豐碩的科研成果,在三大集成方向均取得了多項具有重大國際影響力的突破性研究成果,並培養了一批具有國際競爭力的研究隊伍。其成功實施為我國表觀遺傳總體研究水平的全面提升和跨越式發展做出了重大貢獻。本書介紹了這一重大研究計劃實施情況。

作者介紹
編者:裴鋼|責編:金蕾|總主編:楊衛

目錄
Chapter 1 Project Overview
  1.1  Introduction
    1.1.1  Arrangement and Comprehensive Integration of This MRP
    1.1.2  Interdisciplinary Cooperation
  1.2  Research Overview
    1.2.1  Overall Scientific Objectives
    1.2.2  Key Scientific Issues
  1.3  Significant Progress
Chapter 2 Domestic and Foreign Research
  2.1  Introduction of Epigenetic Research Plans
  2.2  Status Quo of the Epigenetic Research
  2.3  Development Trends of the Epigenetic Research
    2.3.1  Mechanisms of Epigenetic Regulation of Gene Expression
    2.3.2  Discovery, Identification, and Function Studies of New Epigenetic Modifications, Modifying Enzymes, and Reader Proteins
    2.3.3  Mechanisms of Establishment and Maintenance of Epigenetic Information
    2.3.4  Epigenetic Regulation on Reproduction and Development
    2.3.5  Molecular Mechanisms of Epigenetic Regulation on Cell Programming and Reprogramming
    2.3.6  Higher-Order Chromatin Structures and Subnuclear Structures
    2.3.7  Origins and Evolution of Epigenetic Regulatory Networks
    2.3.8  Cancer, Neurodegenerative Diseases and Other Major Diseases Related to Epigenetic Regulation
Chapter 3 Major Research Achievements
  3.1  New Epigenetic Regulators and Chromatin Remodeling Factors as Well as Their Biological Functions and Mechanisms
    3.1.1  New Mechanisms of Interactive Regulation Between DNA Methylation and Histone Methylation Modifications
    3.1.2  New Regulation Mechanisms of DNA Methylase and Demethylase Activities
    3.1.3  New Histone Modification Codes and the Interpretation Mechanisms
    3.1.4  Higher-Order Structure of 30-nm Chromatin Fibers and Their Dynamic Regulation Mechanisms
    3.1.5  Mechanisms of Centromeric Chromatin Establishment and Nucleosome Assembly
    3.1.6  Roles of Histone Variants in Chromatin Assembly
    3.1.7  New Interaction Patterns Between Epigenetic Regulation and DNA Damage Repair
  3.2  Discovery of Epigenetic Regulation Mechanisms for Stem Cell Self-renewal and Somatic Cell Reprogramming, and Breakthroughs in Animal Cloning and Reproductive Technologies
    3.2.1  Establishment of ESCs and Semi Cloning Technologies to Make Artificial Spermatids
    3.2.2  First Utilization of the Polar Body Genome Transfer for Preventing the Transmission of Inherited Mitochondrial Diseases
    3.2.3  The Seesaw Model of Lineage Specifiers Inducing Somatic Cells to iPSC
    3.2.4  Safety Evaluation of Traditional Methods of iPSC Induction by Yamanaka Factors
    3.2.5  Exploration of the Regulation Mechanisms of Somatic Cell Reprogramming and Discovery of New Regulators
    3.2.6  Discovery of New Signals for Maintaining Stem Cell Self-renewal and Developmental Pluripotency
  3.3  Epigenetic Mechanisms Related to Cell Differentiation and Transdifferentiation, Ontogeny, and Diseases
    3.3.1  Discovery of the Key Factors to Promote the Transdifferentiation of Somatic Cells to Hepatocytes

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