內容大鋼
本書被廣泛使用，涵蓋專業人士需了解的各種相關信息，包括如何開具處方、需要注意的不良反應、如何有效增強藥效或更換藥物，例如抗精神病葯、抗抑鬱葯和抗焦慮葯。
第12版基於過往數據回顧和近期臨床實踐，提供了簡單但詳細的精神疾病和相關精神藥理學的綜述。主要介紹血漿藥物水平監測、精神分裂症、雙相情感障礙、抑鬱症、焦慮症、兒童和青少年用藥、藥物濫用，以及特殊患者群體用藥。每部分都有完整的參考文獻，以便在需要時可以快速查詢證據庫。本書還介紹了尚未得到共識的藥物治療，以及藥物與乙醇、煙鹼和咖啡因的相互作用等方面的內容。
初級專業人士通過閱讀本書將獲得關於精神疾病用藥的基礎理論、安全性和療效方面的重要信息。經驗豐富的臨床醫生將會從本書在他們可能不會經常遇到的更複雜的問題上找到很好的指導。
目錄
Preface
Acknowledgements
Notes on using The Maudsley Prescribing Guidelines
List of abbreviations
Chapter 1 Plasma level monitoring of psychotropic drugs
Interpreting sample results
Acting on clozapine plasma concentration results
Interpreting post-mortem blood concentrations
Chapter 2 Schizophrenia
ANTIPSYCHOTIC DRUGS
General introduction
General principles of prescribing
Minimum effective doses
Quick reference for licensed maximum doses
Equivalent doses
High?dose antipsychotics: prescribing and monitoring
Antipsychotic prophylaxis
Combined antipsychotics
Negative symptoms
Monitoring
Relative adverse effects – a rough guide
Treatment algorithms for schizophrenia
First?generation antipsychotics–place in therapy
Omega?3 fatty acid (fish oils) in schizophrenia
New and developing drugs to treat schizophrenia
NICE guidelines for the treatment of schizophrenia
Antipsychotic response – to increase the dose, to switch,to add or just wait – what is the right move?
Antipsychotic long?acting injections
Depot antipsychotics – pharmacokinetics
Management of patients on long?term depots
Aripiprazole LAI
Olanzapine LAI
Paliperidone palmitate LAI
Risperidone LAI
ANTIPSYCHOT ICS – ADVERS E EFFECTS
Extrapyramidal side?effects
Akathisia
Weight gain
Treatment of drug?induced weight gain
Tardive dyskinesia
Neuroleptic malignant syndrome
Catatonia
QT prolongation
Dyslipidaemia
Diabetes and impaired glucose tolerance
Hypertension
Hyponatraemia
Hyperprolactinaemia
Sexual dysfunction
Pneumonia
Switching antipsychotics
REFRACTORY SCHIZOPHRENIA AND CLOZAPINE
Clozapine – dosing regimen
Optimising clozapine treatment
Alternatives to clozapine
Re?starting clozapine after a break in treatment
Initiation of clozapine for community?based patients
CLOZAPINE – ADVERS E EFFECTS
Common adverse effects
Clozapine: uncommon or unusual adverse effects
Clozapine: serious haematological and cardiovascular adverse effects
Clozapine?induced hypersalivation
Clozapine?induced gastrointestinal hypomotility (CIGH)
Clozapine, neutropenia and lithium
Clozapine and chemotherapy
Chapter 3 Bipolar affective disorder
Lithium
Valproate
Carbamazepine
Antipsychotics in bipolar disorder
Treatment of acute mania or hypomania
Bipolar depression
Rapid?cycling bipolar affective disorder
Prophylaxis in bipolar affective disorder
Physical monitoring for people with bipolar affective disorder
Chapter 4 Depression and anxiety
Introduction
Basic principles of prescribing in depression
Official guidance on the treatment of depression
Antidepressants: general overview
St John』s wort
Recognised minimum effective doses of antidepressants
Drug treatment of depression
Treatment of refractory depression
Psychotic depression
Electroconvulsive therapy and psychotropic drugs
Psychostimulants in depression
Post?stroke depression
Treatment of depression in the elderly
Antidepressant discontinuation symptoms
Antidepressant prophylaxis
Antidepressants: alternative routes of administration
Antidepressants: swapping and stopping
Drug interactions with antidepressants
Cardiac effects of antidepressants
Antidepressant?induced arrhythmia
Antidepressant?induced hyponatraemia
Antidepressants and hyperprolactinaemia
Antidepressants and diabetes mellitus
Antidepressants and sexual dysfunction
SSRIs and bleeding
Antidepressants: relative adverse effects – a rough guide
Anxiety spectrum disorders
Benzodiazepines in the treatment of psychiatric disorders
Benzodiazepines: dependence and detoxification
Benzodiazepines and disinhibition
Chapter 5 Children and adolescents
Principles of prescribing practice in childhood and adolescence
Depression in children and adolescents
Bipolar illness in children and adolescents
Psychosis in children and adolescents
Anxiety disorders in children and adolescents
Obsessive compulsive disorder in children and adolescents
Post-traumatic stress disorder in children and adolescents
Attention deficit hyperactivity disorder
Autism spectrum disorders
Tics and Tourette』s syndrome
Melatonin in the treatment of insomnia in children and adolescents
Rapid tranquillisation in children and adolescents
Doses of commonly used psychotropic drugs in children and adolescents
Chapter 6 Substance misuse
Introduction
Alcohol dependence
Opioid misuse and dependence
Nicotine and smoking cessation
Pharmacological treatment of dependence on stimulants
Benzodiazepine misuse
GBL and GHB dependence
Drugs of misuse: a summary
Interactions between 『street drugs』 and prescribed psychotropic drugs
Chapter 7 Use of psychotropic drugs in special patient groups
The elderly
Dementia
Safer prescribing of physical health medicines in dementia
Management of non-cognitive symptoms of dementia
Parkinson』s disease
Multiple sclerosis
Huntington』s disease
Pregnancy
Breastfeeding
Renal impairment
Hepatic impairment
HIV infection
Eating disorders
Acutely disturbed or violent behaviour
Borderline personality disorder
Learning disabilities
Delirium
Epilepsy
Surgery
Velo-cardio-facial syndrome
Cytochrome (CYP) function
Psychiatric side-effects of non-psychotropic drugs
Atrial fibrillation
Chapter 8 Miscellaneous conditions and substances
Psychotropic drugs in overdose
Biochemical and haematological effects of psychotropics
Prescribing drugs outside their licensed indications(『off-label』prescribing)
Observations on the placebo effect in mental illness
Drug interactions with alcohol
Nicotine
Smoking and psychotropic drugs
Caffeine
Complementary therapies
Enhancing medication adherence
Driving and psychotropic medicines
Covert administration of medicines within food and drink
Index
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