內容大鋼
魏冬青、馬亦龍、曹志成、徐沁、周豐豐著的《轉化生物信息學及其應用(英文版)(精)》系「轉化醫學出版工程：技術系列」之一，邀請了國內外生物、醫學、信息學方面的專家學者介紹其最前沿的研究成果，從不同角度展現其研究過程中應用轉化醫學信息學相關方法或工具的實例，主要包括以下兒個方面：(1)組學數據分析協助精準醫療；(2)通過計算生物學方法，探索成藥機制，指導藥物研發；(3)電腦輔助藥物發現，通過定向設計與虛擬篩選更為高效快速地使眾多先導化合物向臨床藥物轉化；(4)利用大數據，通過生物統計學、生物信息學和系統生物學方法研究複雜疾病；(5)生物成像及其他信息學技術在轉化醫學中的應用。本書實用性強，可極大地開拓基礎和臨床醫學工作人員的思路。
目錄
Part I Computer-Aided Drug Discovery
1 Drug Discovery
Geetha Ramakrishnan
2 Translational Bioinformatics and Drug Discovery
Pramodkumar Pyarelal Gupta
3 Translational Research in Drug Discovery and Development
Neha Arora, Pawan Kumar Maurya, and Puneet Kacker
4 Exploring the Potential of Herbal Ligands Toward Multidrug-Resistant Bacterial Pathogens by Computational Drug Discovery
Sinosh Skariyachan
Part II Protein-Ligand Interactions and Drug Development
5 The Progress of New Targets of Anti-HIV and Its Inhibitors
Ke Z. Wu and Ai X. Li
6 Recent Studies on Mechanisms of New Drug Candidates for Alzheimer's Disease Interacting with Amyloid-β Protofibrils Using Molecular Dynamics Simulations
Huai-Meng Fan, Qin Xu, and Dong-Qing Wei
7 Homology Modelling, Structure-Based Pharmacophore Modelling, High-Throughput Virtual Screening and Docking Studies of L-Type Calcium Channel for Cadmium Toxicity
Madhu Sudhana Saddala and A. Usha Rani
8 Natural Compounds Are Smart Players in Context to Anticancer Potential of Receptor Tyrosine Kinases:
An In Silico and In Vitro Advancement
Pushpendra Singh, Shashank Kumar, and Felix Bast
Part III Omics for Precision Medicine
9 Genome-Wide Association Studies: A Comprehensive Tool
to Explore Comparative Genomic Variations and Interactions
Aruni Wilson
10 A Survey of Bioinformatics-Based Tools in RNA-Sequencing
(RNA-Seq) Data Analysis
Pallavi Gaur and Anoop Chaturvedi
11 Epigenetics and Its Role in Human Cancer
Utkarsh Raj and Pritish Kumar Varadwaj
12 Methods for Microhiome Analysis
Kalibulla Syed Ibrahim and Nachimuthu Senthil Kumar
13 Pharmacogenomics: Clinical Perspective, Strategies,and Challenges
Dev Bukhsh Singh
Part IV Biostatistics, Bioinformatics, and System Biology Approaches to Complex Diseases
14 Computational Network Approaches and Their Applications for Complex Diseases
Ankita Shukla and Tiratha Raj Singh
15 Bioinformatics Applications in Clinical Microbiology
Chao Zhang, Shunfu Xu, and Dong Xu
Part V Bioimaging and Other Applications of Informatics Techniques in Translational Medicine
16 Artificial Intelligence and Automatic Image Interpretation in Modern Medicine
Costin Teodor Streba, Mihaela Ionescu, Cristin Constantin Vere, and Ion Rogoveanu
17 Computation in Medicine: Medical Image Analysis and Visualization
Adekunle Micheal Adeshina
Index
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